Beriault Daniel R, Werstuck Geoff H
Thrombosis and Atherosclerosis Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON, Canada.
Exp Diabetes Res. 2012;2012:187018. doi: 10.1155/2012/187018. Epub 2012 Feb 23.
Cardiovascular disease (CVD) is the major cause of mortality in individuals with diabetes mellitus. However the molecular and cellular mechanisms that predispose individuals with diabetes to the development and progression of atherosclerosis, the underlying cause of most CVD, are not understood. This paper summarizes the current state of our knowledge of pathways and mechanisms that may link diabetes and hyperglycemia to atherogenesis. We highlight recent work from our lab, and others', that supports a role for ER stress in these processes. The continued investigation of existing pathways, linking hyperglycemia and diabetes mellitus to atherosclerosis, and the identification of novel mechanisms and targets will be important to the development of new and effective antiatherosclerotic therapies tailored to individuals with diabetes.
心血管疾病（CVD）是糖尿病患者死亡的主要原因。然而，导致糖尿病患者易患动脉粥样硬化（大多数心血管疾病的根本原因）及其发展和进展的分子和细胞机制尚不清楚。本文总结了目前我们对可能将糖尿病和高血糖与动脉粥样硬化发生联系起来的途径和机制的认识。我们重点介绍了我们实验室及其他实验室最近的研究工作，这些工作支持内质网应激在这些过程中发挥作用。持续研究将高血糖和糖尿病与动脉粥样硬化联系起来的现有途径，以及识别新的机制和靶点，对于开发针对糖尿病患者的新型有效抗动脉粥样硬化疗法至关重要。
