McAlpine Cameron S, Werstuck Geoff H
Thrombosis and Atherosclerosis Research Institute, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2.
Cardiovasc Hematol Disord Drug Targets. 2013 Aug;13(2):158-64. doi: 10.2174/1871529x11313020009.
Cardiovascular disease is the number one cause of death worldwide. A major underlying cause of cardiovascular disease is atherosclerosis--a chronic inflammatory disease of the large arteries. Despite substantial advances over the past few decades, our understanding of the molecular mechanisms that link cardiovascular risk factors to the development and progression of atherosclerosis is incomplete. The endoplasmic reticulum (ER) is a membranous organelle found in all eukaryotic cells that is responsible for protein processing and lipid biosynthesis. In recent years it has become evident that disruptions in ER function are associated with a number of human diseases including atherosclerosis. In this review we examine the potential role of endoplasmic reticulum stress in the initiation and progression of atherosclerosis and discuss possible strategies to target this pathway toward the development of new anti-atherogenic therapies.
心血管疾病是全球头号死因。动脉粥样硬化是心血管疾病的一个主要潜在病因，它是一种大动脉的慢性炎症性疾病。尽管在过去几十年里取得了重大进展，但我们对将心血管危险因素与动脉粥样硬化的发生和发展联系起来的分子机制的理解仍不完整。内质网（ER）是所有真核细胞中都存在的一种膜性细胞器，负责蛋白质加工和脂质生物合成。近年来，越来越明显的是，内质网功能紊乱与包括动脉粥样硬化在内的多种人类疾病有关。在这篇综述中，我们研究了内质网应激在动脉粥样硬化发生和发展中的潜在作用，并讨论了针对这一途径开发新的抗动脉粥样硬化疗法的可能策略。
