Division of Nephrology, Department of Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan.
Evid Based Complement Alternat Med. 2012;2012:743107. doi: 10.1155/2012/743107. Epub 2012 Feb 29.
Diabetes mellitus is the most common chronic disease in the world, and a wide range of drugs, including Chinese herbs, have been evaluated for the treatment of associated metabolic disorders. This study investigated the potential hypoglycemic and renoprotective effects of an extract from the solid-state fermented mycelium of Cordyceps sinensis (CS). We employed the KK/HIJ diabetic mouse model, in which the mice were provided with a high-fat diet for 8 weeks to induce hyperglycemia, followed by the administration of CS or rosiglitazone for 4 consecutive weeks. Several parameters were evaluated, including changes in body weight, plasma lipid profiles, oral glucose tolerance tests, insulin tolerance tests, and plasma insulin concentrations. Our results show that the CS extract significantly elevated HDL/LDL ratios at 4 weeks and decreased body weight gain at 8 weeks. Interestingly, CS treatment did not lead to obvious improvements in hyperglycemia or resistance to insulin, while in vitro MTT assays indicated that CS protects pancreatic beta cells against the toxic effects of STZ. CS also enhanced renal NKA activity and reduced the accumulation of mesangial matrix and collagen deposition. In conclusion, CS extract can potentially preserve β-cell function and offer renoprotection, which may afford a promising therapy for DM.
糖尿病是世界上最常见的慢性疾病，包括中草药在内的多种药物已被评估用于治疗相关代谢紊乱。本研究调查了蛹虫草固态发酵菌丝体提取物的潜在降血糖和肾保护作用。我们采用 KK/HIJ 糖尿病小鼠模型，给予高脂饮食 8 周诱导高血糖，然后连续 4 周给予蛹虫草或罗格列酮。评估了多种参数，包括体重变化、血浆脂质谱、口服葡萄糖耐量试验、胰岛素耐量试验和血浆胰岛素浓度。我们的结果表明，蛹虫草提取物在 4 周时显著提高了高密度脂蛋白/低密度脂蛋白比值，在 8 周时降低了体重增加。有趣的是，蛹虫草治疗并没有明显改善高血糖或胰岛素抵抗，而 MTT 测定表明，蛹虫草可保护胰岛β细胞免受 STZ 的毒性作用。蛹虫草还增强了肾脏 NKA 活性，减少了肾小球基质的积累和胶原沉积。综上所述，蛹虫草提取物可能具有保护β细胞功能和肾脏保护作用，为糖尿病治疗提供了一种有前景的方法。
