• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

原发性干燥综合征中的神经系统疾病

Neurological Disorders in Primary Sjögren's Syndrome.

作者信息

Tobón Gabriel J, Pers Jacques-Olivier, Devauchelle-Pensec Valérie, Youinou Pierre

机构信息

EA Immunologie et Pathologie, Université de Bretagne Occidentale et Centre Hospitalier Universitaire de Brest, BP 824, F2969 Brest, France.

出版信息

Autoimmune Dis. 2012;2012:645967. doi: 10.1155/2012/645967. Epub 2012 Mar 5.

DOI:10.1155/2012/645967
PMID:22474573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3303537/
Abstract

Sjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands. The histopathological hallmark is periductal lymphocytic infiltration of the exocrine glands, resulting in loss of their secretory function. Several systemic manifestations may be found in patients with Sjögren's syndrome including neurological disorders. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. This paper endeavors to review the main clinical neurological manifestations in Sjögren syndrome, the physiopathology, and their therapeutic response.

摘要

干燥综合征是一种自身免疫性疾病，其特征是主要累及唾液腺和泪腺的自身免疫性外分泌腺病。组织病理学特征是外分泌腺导管周围淋巴细胞浸润，导致其分泌功能丧失。干燥综合征患者可能会出现多种全身表现，包括神经系统疾病。在不同系列研究中，神经系统受累比例从0%到70%不等，可表现为中枢神经系统和/或周围神经系统受累。本文旨在综述干燥综合征主要的临床神经表现、生理病理学及其治疗反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b22/3303537/9d348af32c34/AD2012-645967.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b22/3303537/9d348af32c34/AD2012-645967.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b22/3303537/9d348af32c34/AD2012-645967.001.jpg

相似文献

1
Neurological Disorders in Primary Sjögren's Syndrome.原发性干燥综合征中的神经系统疾病
Autoimmune Dis. 2012;2012:645967. doi: 10.1155/2012/645967. Epub 2012 Mar 5.
2
Neurological Involvement as the Initial Manifestation in Primary Sjögren's Syndrome - A Case Report.以神经受累为首发表现的原发性干燥综合征——病例报告
Curr Rheumatol Rev. 2019;15(3):254-258. doi: 10.2174/1573397114666180731101142.
3
Lessons from diseases mimicking Sjögren's syndrome.模仿干燥综合征的疾病的经验教训。
Clin Rev Allergy Immunol. 2007 Jun;32(3):275-83. doi: 10.1007/s12016-007-8006-5.
4
Cardiac Manifestations of Sjogren's Syndrome: A Review of Literature.干燥综合征的心脏表现：文献综述
Cureus. 2023 Jun 26;15(6):e41002. doi: 10.7759/cureus.41002. eCollection 2023 Jun.
5
Primary Sjögren's Syndrome Presenting as Recurrent Ischemic Strokes.以复发性缺血性中风为表现的原发性干燥综合征
Neurohospitalist. 2022 Apr;12(2):341-345. doi: 10.1177/19418744211048593. Epub 2021 Sep 23.
6
The geoepidemiology of Sjögren's syndrome.干燥综合征的地理流行病学。
Autoimmun Rev. 2010 Mar;9(5):A305-10. doi: 10.1016/j.autrev.2009.11.004. Epub 2009 Nov 10.
7
Sjögren's syndrome.干燥综合征
Lancet. 2005;366(9482):321-31. doi: 10.1016/S0140-6736(05)66990-5.
8
Current concepts of autoimmune exocrinopathy: immunologic mechanisms in the salivary pathology of Sjögren's syndrome.自身免疫性外分泌腺病的当前概念：干燥综合征唾液病理学中的免疫机制
Crit Rev Oral Biol Med. 1996;7(2):144-58. doi: 10.1177/10454411960070020301.
9
Update on Sjögren's syndrome autoimmune epithelitis: from classification to increased neoplasias.干燥综合征自身免疫性上皮炎的最新进展：从分类到肿瘤发生率增加
Best Pract Res Clin Rheumatol. 2007 Dec;21(6):989-1010. doi: 10.1016/j.berh.2007.09.001.
10
Histopathological changes in exocrine glands of murine transplantation chimeras. II: Sjögren's syndrome-like exocrinopathy in mice without lupus nephritis. A model of primary Sjögren's syndrome.小鼠移植嵌合体的外分泌腺组织病理学变化。II：无狼疮性肾炎小鼠的干燥综合征样外分泌腺病。原发性干燥综合征模型。
Autoimmunity. 1992;11(4):273-80. doi: 10.3109/08916939209035165.

引用本文的文献

1
A 56-year-Old Woman With Initial Severe Electrolyte Imbalance Who Developed Altered Mental Status, Psychosis and Catatonia.一名56岁女性，最初出现严重电解质失衡，随后发展为精神状态改变、精神病和紧张症。
Neurohospitalist. 2025 Aug 1:19418744251364125. doi: 10.1177/19418744251364125.
2
Neurological manifestations of Sjogren syndrome: A case series.干燥综合征的神经学表现：病例系列
J Family Med Prim Care. 2025 Jun;14(6):2558-2560. doi: 10.4103/jfmpc.jfmpc_134_23. Epub 2025 Jun 30.
3
Recommendations on neurologic, cognitive, and psychiatric manifestations in patients with Sjögren's disease by the Brazilian Society of Rheumatology.

本文引用的文献

1
Serum IgA against type 3 muscarinic acetylcholine receptor is a novel marker in diagnosis of Sjögren's syndrome.血清 IgA 针对毒蕈碱型乙酰胆碱受体 3 是干燥综合征诊断的新型标志物。
Chin Med J (Engl). 2011 Aug;124(16):2490-5.
2
Efficacy of rituximab in primary Sjogren's syndrome with peripheral nervous system involvement: results from the AIR registry.利妥昔单抗治疗原发性干燥综合征合并周围神经系统受累的疗效：来自 AIR 登记研究的结果。
Ann Rheum Dis. 2012 Jan;71(1):84-7. doi: 10.1136/annrheumdis-2011-200086. Epub 2011 Sep 16.
3
Experience of intravenous immunoglobulin therapy in neuropathy associated with primary Sjögren's syndrome: a national multicentric retrospective study.
巴西风湿病学会关于干燥综合征患者神经、认知和精神表现的建议。
Adv Rheumatol. 2025 Feb 11;65(1):7. doi: 10.1186/s42358-025-00438-7.
4
Hypophysitis and central nervous system involvement in association with Sjögren's syndrome along with hypoparathyroidism: a case report.干燥综合征合并甲状旁腺功能减退症相关的垂体炎和中枢神经系统受累：一例报告。
BMC Neurol. 2024 Sep 12;24(1):339. doi: 10.1186/s12883-024-03845-3.
5
Exploring the Psychiatric Manifestations of Primary Sjögren's Syndrome: A Narrative Review.探索原发性干燥综合征的精神症状：一项叙述性综述。
Int J Rheumatol. 2024 May 14;2024:5520927. doi: 10.1155/2024/5520927. eCollection 2024.
6
Cerebral large vessels vasculitis following Guillain-Barré syndrome as first clinical manifestations of primary Sjogren's syndrome: A case based - Review.以格林-巴利综合征后大脑大血管血管炎为首发临床表现的原发性干燥综合征：一例病例回顾
Heliyon. 2024 Apr 22;10(9):e30004. doi: 10.1016/j.heliyon.2024.e30004. eCollection 2024 May 15.
7
Cerebrospinal Fluid Analysis in Rheumatological Diseases with Neuropsychiatric Complications and Manifestations: A Narrative Review.伴有神经精神并发症和表现的风湿性疾病中的脑脊液分析：一项叙述性综述
Diagnostics (Basel). 2024 Jan 23;14(3):242. doi: 10.3390/diagnostics14030242.
8
Neurological Involvement in Patients with Primary Sjögren's Syndrome: A Retrospective Cross-Sectional Study.原发性干燥综合征患者的神经受累情况：一项回顾性横断面研究。
Ann Indian Acad Neurol. 2023 Jul-Aug;26(4):424-430. doi: 10.4103/aian.aian_138_23. Epub 2023 Aug 8.
9
Neurological injury in primary Sjogren's syndrome.原发性干燥综合征中的神经损伤
Ann Med Surg (Lond). 2023 Jun 5;85(7):3381-3385. doi: 10.1097/MS9.0000000000000937. eCollection 2023 Jul.
10
Risk of dementia or Parkinson's disease in the presence of Sjögren's syndrome: A systematic review and meta-analysis.干燥综合征患者患痴呆或帕金森病的风险：一项系统评价和荟萃分析。
Front Integr Neurosci. 2022 Nov 7;16:1027044. doi: 10.3389/fnint.2022.1027044. eCollection 2022.
原发性干燥综合征相关神经病采用静脉注射免疫球蛋白治疗的经验：一项全国多中心回顾性研究。
Arthritis Care Res (Hoboken). 2011 Sep;63(9):1339-44. doi: 10.1002/acr.20495.
4
Peripheral neuropathies associated with primary Sjögren syndrome: immunologic profiles of nonataxic sensory neuropathy and sensorimotor neuropathy.与原发性干燥综合征相关的周围神经病：无共济失调性感觉神经病和感觉运动神经病的免疫学特征
Medicine (Baltimore). 2011 Mar;90(2):133-138. doi: 10.1097/MD.0b013e31820fd2d1.
5
Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome.干扰3型毒蕈碱受体通路的抗体可抑制干燥综合征患者的胃肠动力和胆碱能神经传递。
Arthritis Rheum. 2011 May;63(5):1426-34. doi: 10.1002/art.30282.
6
Acute motor axonal neuropathy in association with Sjögren syndrome.与干燥综合征相关的急性运动轴索性神经病。
Muscle Nerve. 2010 Nov;42(5):828-30. doi: 10.1002/mus.21830.
7
[Small fibre neuropathy in primary Sjögren syndrome].[原发性干燥综合征中的小纤维神经病变]
Rev Med Interne. 2011 Mar;32(3):142-8. doi: 10.1016/j.revmed.2010.08.022. Epub 2010 Oct 12.
8
[Small fibre neuropathy: Diagnostic approach and therapeutic issues, and its association with primary Sjögren's syndrome].[小纤维神经病变：诊断方法与治疗问题及其与原发性干燥综合征的关联]
Rev Med Interne. 2010 Oct;31(10):677-84. doi: 10.1016/j.revmed.2010.07.022. Epub 2010 Sep 20.
9
Primary Sjögren's Syndrome: health experiences and predictors of health quality among patients in the United States.原发性干燥综合征：美国患者的健康体验与健康质量预测因素
Health Qual Life Outcomes. 2009 May 27;7:46. doi: 10.1186/1477-7525-7-46.
10
Guillain-Barré syndrome: an update.吉兰-巴雷综合征：最新进展
J Clin Neurosci. 2009 Jun;16(6):733-41. doi: 10.1016/j.jocn.2008.08.033. Epub 2009 Apr 7.