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经鼻给予氨甲环酸治疗遗传性出血性毛细血管扩张症:一例病例报告及治疗选择综述

Intranasal tranexamic acid for the treatment of hereditary hemorrhagic telangiectasia: a case report and review of treatment options.

作者信息

Flanagan Brigitte A, Collins Chris, Parra Sylvia

机构信息

Reid Clinic, Lackland Air Force Base, Texas, USA.

出版信息

Cutis. 2012 Feb;89(2):69-72.

Abstract

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant disorder. The disease has been formally characterized with epistaxis, cutaneous and mucosal telangiectases, a first-degree relative with HHT, and visceral lesions such as arteriovenous malformations (AVMs). Hereditary hemorrhagic telangiectasia has been underreported for many years. Wider recognition of this disorder in recent years has prompted researchers and physicians to recognize milder cases and focus on earlier treatment. This article highlights different treatments used to control epistaxis and screen for other complications associated with HHT.

摘要

遗传性出血性毛细血管扩张症(HHT)是一种常染色体显性疾病。该疾病的正式特征包括鼻出血、皮肤和黏膜毛细血管扩张、有一位患HHT的一级亲属,以及内脏病变,如动静脉畸形(AVM)。遗传性出血性毛细血管扩张症多年来一直未得到充分报道。近年来对这种疾病的更广泛认识促使研究人员和医生识别出症状较轻的病例,并关注早期治疗。本文重点介绍了用于控制鼻出血以及筛查与HHT相关的其他并发症的不同治疗方法。

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