紫新乌檀树皮的化学与生物活性评价

Chemical and bioactivity evaluation of the bark of Neonauclea purpurea.

作者信息

Karaket Netiya, Supaibulwatana Kanyaratt, Ounsuk Supatsara, Bultel-Poncé Valérie, Pham Van Cuong, Bodo Bernard

机构信息

Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

出版信息

Nat Prod Commun. 2012 Feb;7(2):169-70.

PMID:22474944

Abstract

Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and alpha-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC50 values of 6.6 and 11.3 microM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC50 value of 1.19 microM.

摘要

对传统医学中使用的紫新乌檀茎皮甲醇提取物进行生物测定引导的分级分离，得到了2种吲哚生物碱，卡丹宾（1）和α-二氢卡丹宾（2），以及一种喹啉化合物，2,6-二甲氧基-1,4-苯醌（3）。抗疟活性评估表明，化合物2和3对恶性疟原虫氯喹耐药株K1表现出温和的体外抗疟活性，IC50值分别为6.6和11.3 microM。化合物1和2对猴（Vero）细胞无细胞毒性，但化合物3表现出较弱的细胞毒性，IC50值为1.19 microM。