[免疫功能正常患者的巨细胞病毒感染。临床与免疫学考量]

[Cytomegalovirus infection in immunocompetent patients. Clinical and immunological considerations].

作者信息

Colomba Claudia, Lalicata Francesco, Siracusa Lucia, Saporito Laura, Di Bona Danilo, Giammanco Giovanni, De Grazia Simona, Titone Lucina

机构信息

Dipartimento di Scienze per la Promozione della Salute, Sezione di Malattie Infettive, Universita di Palermo, Italy.

出版信息

Infez Med. 2012 Mar;20(1):12-5.

PMID:22475655

Abstract

Cytomegalovirus primary infection is considered dangerous for some kinds of patients: immunocompromised (HIV-infected and transplanted patients), newborns with congenital infection, and immunocompetent patients in critical condition. CMV infection is usually asymptomatic or only mildly symptomatic in immunocompetent hosts. We collected all cases of acute CMV infection that came to our attention during the period November 2009 - May 2011 to analyze their clinical features. Immunoenzymatic methods (ELISA) were used for the detection of specific IgM and IgG antibodies in every case. We observed 73 cases of acute CMV infection. The male-female ratio was 1.5/1. The average age was 36.4. All the patients had fever, 16 (22%) pharyngitis, only 9 (12.3%) lymphadenopathy. The most common complications were hepatitis, encephalitis, pericarditis and pneumonia. Unknown genetic factors may greatly influence the clinical expression of the illness.

摘要

巨细胞病毒原发性感染对某些类型的患者来说被认为是危险的

免疫功能低下者（感染艾滋病毒者和移植患者）、患有先天性感染的新生儿以及处于危急状态的免疫功能正常患者。在免疫功能正常的宿主中，巨细胞病毒感染通常无症状或仅表现出轻微症状。我们收集了2009年11月至2011年5月期间引起我们注意的所有急性巨细胞病毒感染病例，以分析其临床特征。在每个病例中，采用免疫酶法（ELISA）检测特异性IgM和IgG抗体。我们观察到73例急性巨细胞病毒感染病例。男女比例为1.5/1。平均年龄为36.4岁。所有患者均有发热，16例（22%）有咽炎，仅有9例（12.3%）有淋巴结病。最常见的并发症是肝炎、脑炎、心包炎和肺炎。未知的遗传因素可能会极大地影响该疾病的临床表现。