Xie Fang, von Dadelszen Peter, Nadeau Joseph
Am J Reprod Immunol. 2014 Apr;71(4):379-86. doi: 10.1111/aji.12199.
Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early-onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and low platelets syndrome (HELLPs) are unexplored.
A case–control study was performed to examine maternal CMV antibodies, neutrophil Toll-like receptor (TLR)-2 and -4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE-HELLPs) (n = 10), late-onset preeclampsia (LOPE) (n = 20), normal pregnancy (n = 60), and non-pregnancy (n = 20) controls.
EOPE-HELLPs had significantly increased CMV IgG sero-positivity, upregulated TLR-2/-4 mRNA expression, increased serum IL-6 and TNF-α, and reduced IL-10 compared with matched normal and non-pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls.
We observed a significant association between CMV IgG sero-positivity and innate immune response in EOPE-HELLPs. Our data suggest that CMV infection may be a risk factor for this disorder.
先前有报道称巨细胞病毒（CMV）感染与妊娠并发症有关。然而，其在早发型子痫前期（EOPE）伴溶血、肝酶升高和血小板减少综合征（HELLPs）中的血清阳性率及相关Toll样受体（TLR）表达尚未得到研究。
进行了一项病例对照研究，以检测患有HELLPs的早发型子痫前期（EOPE-HELLPs）（n = 10）、晚发型子痫前期（LOPE）（n = 20）、正常妊娠（n = 60）和非妊娠（n = 20）对照组的孕妇CMV抗体、中性粒细胞Toll样受体（TLR）-2和-4表达以及细胞因子谱。
与匹配的正常和非妊娠对照组相比，EOPE-HELLPs的CMV IgG血清阳性率显著增加，TLR-2/-4 mRNA表达上调，血清IL-6和TNF-α增加，IL-10减少。LOPE与正常妊娠对照组之间未观察到显著差异。
我们观察到在EOPE-HELLPs中，CMV IgG血清阳性与先天免疫反应之间存在显著关联。我们的数据表明，CMV感染可能是这种疾病的一个危险因素。
