Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Hypertens Res. 2012 Aug;35(8):843-8. doi: 10.1038/hr.2012.42. Epub 2012 Apr 5.
As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin in the Japanese Arita-cho cohort study.We followed about 2000 subjects in Arita-cho, Saga, Japan as a cohort study, and we enrolled 637 subjects (205 men; 65.1±8.3 years old) who participated in annual health checks from 2005 to 2008 and underwent measurement of the plasma adiponectin level and an oral glucose tolerance test. We monitored the incidence of cardiovascular or cerebrovascular events in these subjects until the end of 2010, discontinuing follow-up at 3 years after the start of enrollment. Subjects with low plasma adiponectin levels (<10.5 ng ml(-1)) had a higher incidence of newly diagnosed cardiovascular diseases such as acute heart failure or acute myocardial infarction than those with high plasma adiponectin levels (≥10.5 ng ml(-1)) over an average of 2.95 years of follow-up. Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (β=0.16), male gender (β=-0.267), homeostasis model assessment of insulin resistance (β=-0.140) and the plasma levels of high-density lipoprotein cholesterol (β=0.104), uric acid (β=-0.13), triglycerides (β=-0.169) and brain natriuretic peptide (β=0.151). The difference in plasma glucose before and 120 min after the intake of a 75-g glucose load did not influence the plasma adiponectin level. The plasma adiponectin level is useful for predicting cardiovascular events, and is a measure of the risk of lifestyle-related diseases.
由于脂联素的血浆水平与代谢综合征和心血管事件有关，因此低血浆脂联素水平可能导致或引发心血管疾病。本研究旨在确定低脂联素水平是否导致心血管事件，并研究影响日本有田町队列研究中脂联素的因素。我们对日本佐贺县有田町的约 2000 名受试者进行了队列研究，并招募了 637 名（205 名男性；65.1±8.3 岁）受试者，他们在 2005 年至 2008 年期间参加了年度健康检查，并接受了血浆脂联素水平和口服葡萄糖耐量试验的检测。我们监测这些受试者的心血管或脑血管事件的发生率，直到 2010 年底，并在招募开始后 3 年停止随访。与高血浆脂联素水平（≥10.5ng/ml）相比，低血浆脂联素水平（<10.5ng/ml）的受试者在平均 2.95 年的随访中发生新诊断的心血管疾病（如急性心力衰竭或急性心肌梗死）的发生率更高。多变量分析显示，在所有受试者中，脂联素水平由以下参数预测：年龄（β=0.16）、男性（β=-0.267）、胰岛素抵抗的稳态模型评估（β=-0.140）和高密度脂蛋白胆固醇（β=0.104）、尿酸（β=-0.13）、甘油三酯（β=-0.169）和脑钠肽（β=0.151）的血浆水平。摄入 75g 葡萄糖负荷前后的血浆葡萄糖水平的差异并不影响血浆脂联素水平。脂联素水平可用于预测心血管事件，是生活方式相关疾病风险的衡量指标。
