Sente Tahnee, Van Berendoncks An M, Hoymans Vicky Y, Vrints Christiaan J
Laboratory for Cellular and Molecular Cardiology Antwerp University Hospital Edegem Belgium; Cardiovascular Diseases, Department of Translational Pathophysiological Research University of Antwerp Wilrijk Belgium.
J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):261-74. doi: 10.1002/jcsm.12086. Epub 2015 Oct 27.
Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF-associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism.
骨骼肌萎缩是慢性心力衰竭（CHF）的常见并发症，与患者预后不良相关。近年来，脂联素被认为在CHF相关的代谢衰竭和肌肉萎缩中起核心作用。本综述讨论了脂联素在CHF中作用的现有知识。将特别强调CHF患者骨骼肌中脂联素抵抗的复杂相互作用机制和细胞内途径。在本综述中，我们提出抵抗过程是多因素的，整合了胰岛素信号传导、线粒体生物发生和神经酰胺代谢产生的异常。
