临床结果与创伤性脑损伤的埃森概念

Clinical results and the Essen concept of TBI.

作者信息

Molls M, Quast U, Schaefer U W, Szy D, Beelen D W, Quabeck K, Graeven U, Sayer H G, Bamberg M, Sack H

机构信息

Department of Radiotherapy, West German Tumour Centre, University Hospital, Essen.

出版信息

Radiother Oncol. 1990;18 Suppl 1:121-4. doi: 10.1016/0167-8140(90)90190-8.

DOI:10.1016/0167-8140(90)90190-8

PMID:2247635

Abstract

Total body irradiation (TBI) prior to bone marrow transplantation (BMT) is applied for treatment of 230 patients in the period 1975-1988. The clinical results of 169 patients treated by four different TBI dosage and treatment techniques are analysed. The risk of leukemic relapse is low after fractionated TBI (9%) as well as after single dose TBI (14%). The lowest frequency of interstitial pneumonitis (21%) occurred when the patient translation technique was used for fractionated homogeneous pa/ap TBI with 10 Gy (8 Gy lung dose) in 4 fractions in 4 days. Prophylaxis of GVHD and the modus of protective environment were two other factors which influence the risk of IP.

摘要

1975年至1988年期间，230例患者在骨髓移植（BMT）前接受了全身照射（TBI）。分析了169例采用四种不同TBI剂量和治疗技术治疗的患者的临床结果。分次TBI（9%）和单次剂量TBI（14%）后白血病复发风险较低。当患者平移技术用于分次均匀pa/ap TBI，总剂量10 Gy（肺部剂量8 Gy），分4次在4天内给予时，间质性肺炎的发生率最低（21%）。移植物抗宿主病（GVHD）的预防和保护环境的方式是影响IP风险的另外两个因素。