用于骨髓移植的分次全身照射：66例患者的临床结果
Fractionated total body irradiation for bone marrow transplantation: clinical results on 66 patients.
作者信息
Valls A, Ferrer E, Algara M, Rubio A, Grañena A
机构信息
Servicio de Radioterapia, Hospital de la Esperanza, Barcelona, Spain.
出版信息
Radiother Oncol. 1990;18 Suppl 1:151-4. doi: 10.1016/0167-8140(90)90198-6.
Short term clinical results of bone marrow transplantation on 66 patients conditioned with fractionated total body irradiation (12 Gy in 6 fractions and 3 days) are presented here. An acute toxic effects incident, similar to that obtained previously, a 27.6% interstitial pneumonitis associated with acute severe graft versus host disease in 77% of cases, 19.2% relapses, and 41% total crude survival with an actuarial probability of surviving for more than two years of 46% for ALL, 64% for AML and 28% for CML, are the results obtained since now.
本文介绍了对66例接受分次全身照射（6次，每次2Gy，共3天，总剂量12Gy）预处理的患者进行骨髓移植的短期临床结果。目前获得的结果包括：出现了与之前类似的急性毒性事件，27.6%的患者发生间质性肺炎，其中77%的病例伴有急性重度移植物抗宿主病，19.2%的患者复发，总粗生存率为41%，急性淋巴细胞白血病（ALL）患者两年以上的精算生存概率为46%，急性髓细胞白血病（AML）患者为64%，慢性粒细胞白血病（CML）患者为28%。
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