Australian Animal Health Laboratory, CSIRO, Geelong, Australia.
Curr Top Microbiol Immunol. 2012;359:105-21. doi: 10.1007/82_2012_210.
Hendra virus (HeV) and Nipah virus (NiV) form a separate genus Henipavirus within the family Paramyxoviridae, and are classified as biosafety level 4 pathogens due to their high case fatality rate following human infection and because of the lack of effective vaccines or therapy. Both viruses emerged from their natural reservoir during the last decade of the twentieth century, causing severe disease in humans, horses and swine, and infecting a number of other mammalian species. The current review summarizes our up to date understanding of pathology and pathogenesis in the natural reservoir species, the Pteropus bat, and in the equine and porcine spill over species.
亨德拉病毒（HeV）和尼帕病毒（NiV）在副黏病毒科中形成一个单独的亨尼帕病毒属，由于人类感染后的高病死率以及缺乏有效的疫苗或治疗方法，被归类为生物安全 4 级病原体。这两种病毒都是在 20 世纪最后十年从其自然宿主中出现的，导致人类、马和猪严重发病，并感染了许多其他哺乳动物物种。本综述总结了我们目前对其自然宿主物种（狐蝠）以及马和猪溢出物种的病理学和发病机制的理解。
