Department of Chemistry, Anna University, Guindy, Chennai, India.
J Mater Sci Mater Med. 2012 Jun;23(6):1421-30. doi: 10.1007/s10856-012-4610-x. Epub 2012 Apr 3.
The recent advances in electrospinning have resulted in technologies facilitating easy drug entrapment, obtaining high surface area and thereby higher drug loading and release efficacy, burst control as well as the specific morphology which could be controlled according to the desired requirement. The present study focused on the fabrication of collagen/poly(N-isopropyl acrylamide)/chitosan complex with incorporated 5-fluorouracil, an anticancer drug by the method of electrospinning. The effect of chitosan on the fiber morphology and release kinetics was analyzed by varying its concentration. The release kinetics showed that the increase in chitosan concentration delayed the release of the drug from the fiber network. Nano hydroxyapatite was added to the fiber matrix in order to impart bioactivity, which was confirmed by studies in simulated body fluid. The addition of poly(N-isopropyl acrylamide) increased the blood compatibility of the prepared model. Thus, the model prepared to can find potential application in the field of cancer therapy as a drug-delivery agent in post-surgical treatment of cancer and as blood contacting biomaterial.
静电纺丝技术的最新进展使得药物易于包埋、获得高表面积，从而提高药物负载和释放效果、控制药物释放速度以及获得特定形态成为可能，这些形态可以根据需要进行控制。本研究通过静电纺丝的方法，专注于制备胶原蛋白/聚（N-异丙基丙烯酰胺）/壳聚糖复合载有 5-氟尿嘧啶（一种抗癌药物）的纤维。通过改变壳聚糖的浓度来分析其对纤维形态和释放动力学的影响。释放动力学表明，壳聚糖浓度的增加会延迟药物从纤维网络中的释放。纳米羟基磷灰石被添加到纤维基质中以赋予生物活性，这一点通过在模拟体液中的研究得到了证实。聚（N-异丙基丙烯酰胺）的添加提高了所制备模型的血液相容性。因此，所制备的模型可以作为药物传递剂在癌症手术后的治疗中以及作为血液接触生物材料在癌症治疗领域找到潜在的应用。
