Fu Yike, Li Xiang, Ren Zhaohui, Mao Chuanbin, Han Gaorong
State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, P.R. China.
Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019-5300, USA.
Small. 2018 Jun 27:e1801183. doi: 10.1002/smll.201801183.
Localized cancer treatment is one of the most effective strategies in clinical destruction of solid tumors at early stages as it can minimize the side effects of cancer therapeutics. Electrospun nanofibers have been demonstrated as a promising implantable platform in localized cancer treatment, enabling the on-site delivery of therapeutic components and minimizing side effects to normal tissues. This Review discusses the recent cutting-edge research with regard to electrospun nanofibers used for various therapeutic approaches, including gene therapy, chemotherapy, photodynamic therapy, thermal therapy, and combination therapy, in enhancing localized cancer treatment. Furthermore, it extensively analyzes the current challenges and potential breakthroughs in utilizing this novel platform for clinical transition in localized cancer treatment.
局部癌症治疗是临床早期实体瘤破坏中最有效的策略之一，因为它可以将癌症治疗的副作用降至最低。电纺纳米纤维已被证明是局部癌症治疗中一个很有前景的可植入平台，能够实现治疗成分的原位递送，并将对正常组织的副作用降至最低。本综述讨论了有关用于各种治疗方法的电纺纳米纤维的最新前沿研究，包括基因治疗、化疗、光动力治疗、热疗和联合治疗，以加强局部癌症治疗。此外，它还广泛分析了利用这一新型平台实现局部癌症治疗临床转化的当前挑战和潜在突破。
