Essig M, Dinkel J, Zamecnik C
Abteilung Neuroradiologie, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054 Erlangen.
Radiologe. 2012 Mar;52(3):229-34. doi: 10.1007/s00117-011-2197-8.
Therapy-related side effects, which are detectable with magnetic resonance imaging (MRI) at high sensitivity, are one of the most frequent causes of morbidity in cancer patients. They can be observed in the treatment of central nervous system (CNS) diseases as well as in systemic therapy, including whole brain irradiation and chemotherapy and are more often seen due to the better overall survival. This review describes the most frequent acute and chronic therapy-related changes in the CNS and the imaging findings. Acute changes are often reversible while chronic changes can be observed up to several years after treatment.The differentiation of treatment-related from tumor-related changes might be very difficult, although modern imaging modalities such as MR spectroscopy or MR perfusion measurements supply helpful differential diagnostic information.
与治疗相关的副作用在磁共振成像（MRI）下具有高敏感性，可被检测到，是癌症患者发病的最常见原因之一。在中枢神经系统（CNS）疾病治疗以及全身治疗（包括全脑照射和化疗）中均可观察到这些副作用，且由于总体生存率提高，其更为常见。本综述描述了中枢神经系统中最常见的急性和慢性治疗相关变化以及影像学表现。急性变化通常是可逆的，而慢性变化在治疗后数年仍可观察到。尽管磁共振波谱或磁共振灌注测量等现代成像方式可提供有用的鉴别诊断信息，但区分治疗相关变化和肿瘤相关变化可能非常困难。
