Mechatronics Engineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Orhanli, Tuzla, Istanbul, Turkey.
Ann Biomed Eng. 2012 Sep;40(9):1895-902. doi: 10.1007/s10439-012-0559-7. Epub 2012 Apr 3.
The objective of this study is to reveal the potential of micro scale hydrodynamic bubbly cavitation for the use of kidney stone treatment. Hydrodynamically generated cavitating bubbles were targeted to the surfaces of 18 kidney stone samples made of calcium oxalate, and their destructive effects were exploited in order to remove kidney stones in in vitro experiments. Phosphate buffered saline (PBS) solution was used as the working fluid under bubbly cavitating conditions in a 0.75 cm long micro probe of 147 μm inner diameter at 9790 kPa pressure. The surface of calcium oxalate type kidney stones were exposed to bubbly cavitation at room temperature for 5 to 30 min. The eroded kidney stones were visually analyzed with a high speed CCD camera and using SEM (scanning electron microscopy) techniques. The experiments showed that at a cavitation number of 0.017, hydrodynamic bubbly cavitation device could successfully erode stones with an erosion rate of 0.31 mg/min. It was also observed that the targeted application of the erosion with micro scale hydrodynamic cavitation may even cause the fracture of the kidney stones within a short time of 30 min. The proposed treatment method has proven to be an efficient instrument for destroying kidney stones.
本研究旨在揭示微尺度流体力空化在肾结石治疗中的应用潜力。针对由草酸钙制成的 18 个肾结石样本表面生成的流体力空化气泡，并利用其破坏性效应进行了体外实验以去除肾结石。在 9790kPa 压力下，以 0.75cm 长、147μm 内径的微探头中的磷酸盐缓冲盐水 (PBS) 溶液作为工作流体，在空化条件下使草酸钙肾结石样本表面暴露于空化气泡中 5 至 30 分钟。利用高速 CCD 相机和 SEM（扫描电子显微镜）技术对被侵蚀的肾结石进行了直观分析。实验表明，在空化数为 0.017 的情况下，流体力空化装置可以成功地以 0.31mg/min 的侵蚀速率侵蚀结石。还观察到，在 30 分钟的短时间内，通过微尺度流体力空化的靶向侵蚀甚至可能导致肾结石的破裂。所提出的治疗方法已被证明是一种有效的肾结石破坏仪器。
