UMRS, Laboratoire d'Imagerie Fonctionnelle, Inserm, UPMC Univ Paris, France.
Brain Imaging Behav. 2012 Jun;6(2):283-92. doi: 10.1007/s11682-012-9159-2.
The presence of a postconcussion syndrome (PCS) induces substantial socio-professional troubles in mild traumatic brain injury (mTBI) patients. Although the exact origin of these disorders is not known, they may be the consequence of diffuse axonal injury (DAI) impacting structural integrity. In the present study, we compared structural integrity at the subacute and late stages after mTBI and in case of PCS, using diffusion-weighted imaging (DWI). Fifty-three mTBI patients were investigated and compared with 40 healthy controls. All patients underwent a DWI examination at the subacute (8-21 days) and late (6 months) phases after injury. MTBI patients with PCS were detected at the subacute phase using the ICD-10 classification. Groupwise differences in structural integrity were investigated using Tract-Based Spatial Statistics (TBSS). A loss of structural integrity was found in mTBI patients at the subacute phase but partially resolved over time. Moreover, we observed that mTBI patients with PCS had greater and wider structural impairment than patients without PCS. These damages persisted over time for PCS patients, while mTBI patients without PCS partly recovered. In conclusion, our results strengthen the relationship between structural integrity and PCS.
脑震荡后综合征（PCS）的存在会给轻度创伤性脑损伤（mTBI）患者带来严重的社会职业困扰。尽管这些疾病的确切起源尚不清楚，但它们可能是影响结构完整性的弥漫性轴索损伤（DAI）的后果。在本研究中，我们使用弥散加权成像（DWI）比较了 mTBI 后亚急性期和晚期以及 PCS 病例的结构完整性。对 53 名 mTBI 患者和 40 名健康对照进行了研究。所有患者在损伤后 8-21 天和 6 个月的亚急性期和晚期进行 DWI 检查。使用 ICD-10 分类在亚急性期检测到 mTBI 患者的 PCS。使用基于束的空间统计学（TBSS）研究结构完整性的组间差异。在亚急性期，mTBI 患者的结构完整性丧失，但随着时间的推移部分恢复。此外，我们观察到患有 PCS 的 mTBI 患者的结构损伤比没有 PCS 的患者更大、更广泛。这些损伤在 PCS 患者中持续存在，而没有 PCS 的 mTBI 患者则部分恢复。总之，我们的研究结果加强了结构完整性与 PCS 之间的关系。
