Dean Philip J A, Otaduy Maria C G, Harris Lisa M, McNamara Adam, Seiss Ellen, Sterr Annette
Department of Psychology, University of Surrey, Guildford, Surrey, UK.
Neuroreport. 2013 Aug 21;24(12):677-81. doi: 10.1097/WNR.0b013e3283637aa4.
This pilot study explores the metabolic changes associated with persistent postconcussion syndrome (PCS) after mild traumatic brain injury (mTBI; >12 months after injury) using magnetic resonance spectroscopy. We hypothesized that those mTBI participants with PCS will have larger metabolic differences than those without. Data were collected from mTBI participants with PCS, mTBI participants without PCS and non-head-injured participants (all groups: n=8). Magnetic resonance spectroscopy metabolite profiles within the dorsolateral prefrontal cortex showed a reduced creatine/choline ratio in mTBI patients compared with control participants. This data provides initial evidence for residual metabolic changes in chronic mTBI patients, but there was no conclusive relationship between these metabolic changes and PCS symptom report. Creatine is involved in maintaining energy levels in cells with high or fluctuating energy demand, suggesting that there may be some residual energy impairment in chronic mTBI.
这项初步研究利用磁共振波谱技术，探索轻度创伤性脑损伤（mTBI；受伤12个月后）后与持续性脑震荡后综合征（PCS）相关的代谢变化。我们假设，患有PCS的mTBI参与者比未患PCS的参与者有更大的代谢差异。数据收集自患有PCS的mTBI参与者、未患PCS的mTBI参与者和非头部受伤参与者（所有组：n = 8）。与对照参与者相比，背外侧前额叶皮层内的磁共振波谱代谢物谱显示mTBI患者的肌酸/胆碱比值降低。该数据为慢性mTBI患者残留的代谢变化提供了初步证据，但这些代谢变化与PCS症状报告之间没有确凿的关系。肌酸参与维持能量需求高或波动的细胞中的能量水平，这表明慢性mTBI可能存在一些残留的能量损伤。
