Hurley Anne M, Tadrous Mina, Miller Elizabeth S
Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee.
J Pediatr Pharmacol Ther. 2010 Jul;15(3):173-81.
Although epidemiologic evidence has not supported the hypothesis of a causal relationship between thimerosal-containing vaccines and autism, concerns continue about pediatric exposure to mercury through vaccine administration. A statement issued by the American Academy of Pediatrics and the US Public Health Service in 1999 prompted the removal of thimerosal from many vaccines. In 2004, the Immunization Safety Review Committee of the Institute of Medicine rejected the hypothesis of a causal relationship between thimerosal-containing vaccines and autism.In a search of MEDLINE and EMBASE, we identified articles that address the potential association between thimerosal and neurodevelopmental disorders, specifically autism. In this article, we review recent pharmacokinetic and epidemiologic studies published between 2003 and 2008 regarding the proposed link between thimerosal and autism.
尽管流行病学证据并不支持含硫柳汞疫苗与自闭症之间存在因果关系的假说，但人们仍对儿童通过接种疫苗接触汞的情况感到担忧。1999年美国儿科学会和美国公共卫生服务局发布的一份声明促使许多疫苗中不再使用硫柳汞。2004年，医学研究所的免疫安全审查委员会驳回了含硫柳汞疫苗与自闭症之间存在因果关系的假说。在检索MEDLINE和EMBASE时，我们识别出了探讨硫柳汞与神经发育障碍（特别是自闭症）之间潜在关联的文章。在本文中，我们回顾了2003年至2008年间发表的有关硫柳汞与自闭症之间假定联系的最新药代动力学和流行病学研究。
