McCafferty M C
Moredun Research Institute, Edinburgh, Great Britain.
Vet Microbiol. 1990 Oct;25(1):87-99. doi: 10.1016/0378-1135(90)90096-e.
Chlamydia psittaci, a zoonotic bacterium, is the causal agent of enzootic abortion of ewes, an important disease of sheep in many European countries. The major thrust of current chlamydial research is directed towards the human pathogen Chlamydia trachomatis. This review attempts to bring together relevant information concerning the host immune response to all members of the genus Chlamydiae and show how this has led to an increased understanding of the ovine humoral and cell mediated immune responses to C. psittaci while emphasising areas where there is still a lack of knowledge. Specifically the review looks at the common immuno-accessible antigens of the Chlamydiae and the antibody responses produced during infection, as well as covering the role of T cells and cytokines in the protective immune response.
鹦鹉热衣原体是一种人畜共患病菌，是母羊地方性流产的病原体，在许多欧洲国家是绵羊的一种重要疾病。当前衣原体研究的主要方向是针对人类病原体沙眼衣原体。本综述试图汇集有关宿主对衣原体属所有成员免疫反应的相关信息，并展示这如何增进了对绵羊对鹦鹉热衣原体体液免疫和细胞介导免疫反应的理解，同时强调仍缺乏知识的领域。具体而言，该综述着眼于衣原体常见的免疫可及抗原以及感染期间产生的抗体反应，还涵盖了T细胞和细胞因子在保护性免疫反应中的作用。
