Vasilescu C, Olteanu M, Flondor P
University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Chirurgia (Bucur). 2012 Jan-Feb;107(1):22-6.
In a recent paper the authors hypothesized that the so called fractal-like enzyme kinetics of intracellular reactions may explain the preconditioning effect in biology (Vasilescu C, Olteanu M, Flondor P, Revue Roumaine de Chimie. 2011; 56(7): 751-7). Inside cells the reaction kinetics is very well described by fractal-like kinetics. In the present work some clinical implications of this model are analyzed. Endotoxin tolerance is a particular case of preconditioning and shows similarities with the immunodepression seen in some sepsis patients. This idea offers a theoretical support for modulation of the enzymatic activity of the cell by changing the fractal dimension of the cytoskeleton.
在最近的一篇论文中，作者推测细胞内反应中所谓的类分形酶动力学可能解释生物学中的预处理效应（瓦西莱斯库C、奥尔泰亚努M、弗隆多尔P，《罗马尼亚化学评论》。2011年；56(7): 751 - 7）。在细胞内，反应动力学可以用类分形动力学很好地描述。在本研究中，分析了该模型的一些临床意义。内毒素耐受是预处理的一种特殊情况，并且与一些脓毒症患者出现的免疫抑制有相似之处。这一观点为通过改变细胞骨架的分形维数来调节细胞的酶活性提供了理论支持。
