Division of Hematology and Oncology, Department of Medicine, George Washington University Medical Center, Washington, District of Columbia 20037, USA.
Cancer Invest. 2012 May;30(4):300-8. doi: 10.3109/07357907.2012.658936. Epub 2012 Apr 5.
Soft tissue sarcomas are a heterogeneous group of mesenchymal tumors that vary in their behavior as well as treatment. Certain histologic subtypes predict for response to particular chemotherapy drugs, while molecular genetics not only increasingly aid in the diagnosis but also has an emerging role in the identification of potential targets for drug therapy. Herein we review the varying soft tissue sarcoma subtypes, their staging, and management. Furthermore, improvement in the understanding of novel mechanisms involved in soft tissue sarcomas lends insight into the compelling role of the use of newer agents with promising results that are discussed.
软组织肉瘤是一组异质性的间叶肿瘤，其行为和治疗方式各不相同。某些组织学亚型可预测对特定化疗药物的反应，而分子遗传学不仅越来越有助于诊断，而且在确定潜在的药物治疗靶点方面也发挥着新兴作用。本文回顾了不同的软组织肉瘤亚型、分期和治疗方法。此外，对软组织肉瘤中涉及的新机制的认识的提高，使人们深入了解使用有前途的新型药物的强烈作用，讨论了这些新型药物的结果。
