Department of Cardiac Surgery, Quebec Heart and Lung University Institute, Quebec City, Quebec, Canada.
Ann Thorac Surg. 2012 May;93(5):1432-7. doi: 10.1016/j.athoracsur.2012.02.033. Epub 2012 Apr 4.
We sought to determine the impact of the completeness of surgical revascularization among octogenarians with triple-vessel disease.
Between 1992 and 2008, 476 consecutive patients aged 80 years or more who underwent primary isolated coronary artery bypass grafting (CABG) procedures were identified. Early and late survival were compared among patients who underwent complete revascularization (CR, n=391) and incomplete revascularization (IR, n=85). IR was present when 1 or more of the 3 main coronary arteries with 50% or greater stenosis that were identified preoperatively as a surgical target by the operating surgeon were not grafted. The mean follow-up was 5.4±3.0 years (maximum 15.3 years).
Baseline risk was similar between the 2 groups of patients. IR was more frequent in off-pump compared with on-pump CABG (34.9% versus 16.2%, respectively; p=0.002). The most common reason for IR was small or severely diseased arteries (87%). The incidence of postoperative myocardial infarction (MI) was similar in both groups (CR, 18.4% versus IR, 17.3%; p=0.81). In-hospital mortality was 7.2% among patients with CR and 4.7% among patients with IR (p=0.60). Three, 5-, and 8-year freedom from all-cause mortality among patients who underwent CR were 89.2%, 74.1%, and 54.3%, respectively, and were not significantly different from those patients who underwent IR (86.6%, 74.5%, and 49.4%, respectively) (p=0.40).
In octogenarians with triple-vessel disease, a strategy of incomplete revascularization during CABG does not negatively impact early or long-term survival.
我们旨在确定 80 岁以上三支病变患者外科血运重建完全性的影响。
1992 年至 2008 年期间,我们确定了 476 例连续的 80 岁或 80 岁以上接受单纯冠状动脉旁路移植术(CABG)的患者。我们比较了接受完全血运重建(CR)的患者(n=391)和不完全血运重建(IR)的患者(n=85)的早期和晚期存活率。如果术前由术者确定的 3 支主要冠状动脉中有 1 支或更多支存在 50%或以上狭窄,但未进行搭桥术,则认为存在 IR。平均随访时间为 5.4±3.0 年(最长 15.3 年)。
两组患者的基线风险相似。非体外循环 CABG 中 IR 比体外循环 CABG 更常见(分别为 34.9%和 16.2%;p=0.002)。IR 最常见的原因是小或严重病变的动脉(87%)。两组术后心肌梗死(MI)的发生率相似(CR,18.4%与 IR,17.3%;p=0.81)。CR 患者的住院死亡率为 7.2%,IR 患者为 4.7%(p=0.60)。CR 患者的 3 年、5 年和 8 年全因死亡率分别为 89.2%、74.1%和 54.3%,与接受 IR 的患者无显著差异(分别为 86.6%、74.5%和 49.4%)(p=0.40)。
在三支病变的 80 岁以上患者中,CABG 时不完全血运重建的策略不会对早期或长期生存率产生负面影响。