Implantation of orthobiologic, biodegradable scaffolds in osteochondral repair.

The treatment of articular cartilage lesions is complicated, but novel tissue engineering approaches seem to improve the outcome. A tissue engineering approach is less invasive and reduces surgical time, periosteal hypertrophy, and morbidity. Cell-based therapies using scaffolds have advantages compared with microfracture techniques, but the efficacy and cost-effectiveness need to be investigated. Second-generation cell-based therapies have lower morbidity and the ease of the technique is not significantly different from that of first-generation autologous chondrocyte implantation techniques. Third-generation cell-based therapies such as the use of tissue engineered scaffolds need to be studied in more detail.