Lupescu Ștefan, Munteanu Corneliu, Sindilar Eusebiu Viorel, Istrate Bogdan, Mihai Iuliana, Oprisan Bogdan, Pasca Aurelian-Sorin
Department of Mechanics and Technologies, Stefan cel Mare University of Suceava, 13 University Street, 720229 Suceava, Romania.
Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania.
Materials (Basel). 2022 Aug 29;15(17):5958. doi: 10.3390/ma15175958.
The medical field has undergone constant development in recent years, and a segment of this development is occupied by biodegradable alloys. The most common alloys in this field are those based on Mg, their main advantage being the ability to degrade gradually, without affecting the patient, and also their ability to be fully absorbed by the human body. One of their most important conditions is the regeneration and replacement of human tissue. Tissue can be engineered in different ways, one being tissue regeneration in vivo, which can serve as a template. In vivo remodeling aims to restore tissue or organs. The key processes of tissue formation and maturation are: proliferation (sorting and differentiation of cells), proliferation and organization of the extracellular matrix, biodegradation of the scaffold-remodeling, and potential tissue growth. In the present paper, the design of the alloys in the Mg-Ca-Y system is formed from the beginning using high-purity components, Mg-98.5%, master-alloys: Mg-Y (70 wt.%-30 wt.%) and Mg-Ca (85 wt.%-15 wt.%). After 8 weeks of implantation, the degradation of the implanted material is observed, and only small remaining fragments are found. At the site of implantation, no inflammatory reaction is observed, but it is observed that the process of integration and reabsorption, over time, accentuates the prosaic surface of the material. The aim of the work is to test the biocompatibility of magnesium-based alloys on laboratory rats in order to use these alloys in medical applications. The innovative parts of these analyses are the chemical composition of the alloys used and the tests performed on laboratory animals.
近年来，医学领域不断发展，其中一部分发展是由可生物降解合金占据的。该领域最常见的合金是基于镁的合金，其主要优点是能够逐渐降解，而不影响患者，并且能够被人体完全吸收。它们最重要的条件之一是人体组织的再生和替换。组织可以通过不同方式构建，一种是体内组织再生，它可以作为模板。体内重塑旨在恢复组织或器官。组织形成和成熟的关键过程包括：增殖（细胞的分选和分化）、细胞外基质的增殖和组织化、支架重塑的生物降解以及潜在的组织生长。在本文中，Mg-Ca-Y 体系合金的设计从一开始就使用高纯度成分，镁含量为 98.5%，中间合金为：Mg-Y（70 wt%-30 wt%）和 Mg-Ca（85 wt%-15 wt%）。植入 8 周后，观察到植入材料的降解，仅发现少量残留碎片。在植入部位，未观察到炎症反应，但观察到随着时间的推移，整合和再吸收过程使材料表面变得平淡无奇。这项工作的目的是在实验室大鼠身上测试镁基合金的生物相容性，以便将这些合金用于医疗应用。这些分析的创新之处在于所用合金的化学成分以及对实验动物进行的测试。
