Griggs R C
University of Rochester, School of Medicine and Dentistry, Department of Neurology, NY 14642.
Adv Exp Med Biol. 1990;280:235-40. doi: 10.1007/978-1-4684-5865-7_27.
Initial trials of myoblast transfer into individual muscles should include studies of regional muscle mass. Magnetic resonance imaging is a safe and accurate technique that should be studied in the context of these trials. Creatinine excretion should also be measured in order to provide baseline information for future studies of myoblast injections into a larger number of muscles. In vivo assessment of muscle protein synthesis can be combined with histologic study to determine if the treatment alters the rate of protein synthesis.
将成肌细胞移植到单个肌肉的初步试验应包括对局部肌肉质量的研究。磁共振成像是一种安全且准确的技术，应在这些试验的背景下进行研究。还应测量肌酐排泄量，以便为未来将成肌细胞注射到更多肌肉中的研究提供基线信息。肌肉蛋白质合成的体内评估可与组织学研究相结合，以确定该治疗是否会改变蛋白质合成速率。
