Department of Otorhinolaryngology, Philipps University, Baldingerstrasse, 35033 Marburg, Germany.
Arch Gynecol Obstet. 2012 Aug;286(2):473-80. doi: 10.1007/s00404-012-2307-5. Epub 2012 Apr 6.
Most patients with epithelial ovarian cancer have a poor overall prognosis. Therefore, one of the main therapeutic aims after cytoreductive surgery for these patients is to identify, delay and relieve chemotherapy-induced side effects and optimise the quality of life, especially after first-line therapy.
Twelve ovarian cancer patients undergoing carboplatinum-containing chemotherapy were assessed using validated tests for olfactory, gustatory, and hearing functions before, during, immediately after, and 3 months after chemotherapy.
All chemosensory functions decreased during and after carboplatinum-containing chemotherapy, but recovered 3 months after treatment ended. For olfaction, this decrease was significant, affecting odour identification minimally, and odour threshold the most. For taste, the decrease was not significant, but could be observed in total scores and in each quality (sweet, sour, salty, and bitter). For hearing, the decrease was not significant, but a recovery of the deep and middle frequencies was clearly evident 3 months after chemotherapy.
Patients must be informed about transient declines in chemosensory functions during chemotherapy. Symptomatic relief provided by the use of more spices, a small amount of glutamate, or additional flavouring might help to compensate for decreased functions during chemotherapy and increase patient quality of life.
大多数上皮性卵巢癌患者的总体预后较差。因此，这些患者在接受细胞减灭术后的主要治疗目标之一是识别、延迟和缓解化疗引起的副作用，并优化生活质量，特别是在一线治疗后。
对 12 名接受含卡铂化疗的卵巢癌患者，在化疗前、化疗期间、化疗结束后立即以及化疗结束后 3 个月，使用经过验证的嗅觉、味觉和听力功能测试进行评估。
所有的化学感觉功能在含卡铂的化疗期间和之后都下降了，但在治疗结束后 3 个月恢复。嗅觉方面，这种下降是显著的，对气味识别的影响最小，对气味阈值的影响最大。味觉方面，下降不显著，但在总分和每个味觉（甜、酸、咸、苦）中都可以观察到。听力方面，下降不显著，但在化疗结束后 3 个月，深、中频的恢复明显。
必须告知患者化疗期间化学感觉功能会短暂下降。使用更多的香料、少量谷氨酸或额外的调味料来缓解症状，可能有助于补偿化疗期间功能下降，提高患者的生活质量。
