Walliczek-Dworschak Ute, Gudziol Volker, Mitzschke Claudia, Froehner Michael, Hummel Thomas
Department of Otorhinolaryngology, Smell and Taste Clinic, Interdisciplinary Center Smell and Taste, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Department of Otorhinolaryngology, Philipps-University, Marburg, Germany.
Eur Arch Otorhinolaryngol. 2017 Jul;274(7):2813-2818. doi: 10.1007/s00405-017-4559-y. Epub 2017 Apr 20.
Testicular cancer is the most frequent malignant disease in young males between 15 and 35 years. Platinum based chemotherapy regimen is the therapy of choice in advanced disease. This treatment has also adverse effects caused by the cytostatic active substances, such as olfactory dysfunctions. The aim of this study was, therefore, to monitor olfactory function of testicular cancer patients during and 6 months after chemotherapy. A total of 17 patients (mean age 31.06 ± 10.26 years), which underwent chemotherapy (mean 2.47 cycles ± 0.5) were enrolled in this study. Odor threshold, discrimination and identification were assessed by means of the "Sniffin' Sticks" prior to and on day 42, 90 and 180 after chemotherapy has been completed. Furthermore, patients' ratings of olfactory function and depressive symptoms were evaluated. Threshold scores were significantly lower on day 90 (8.0 ± 2.51) compared to baseline (10.4 ± 2.20) (p = 0.014) and recovered almost completely on day 180 (9.65 ± 3.26). Odor discrimination and identification did not show significant changes during therapy. The decrease of the olfactory function during/immediately after chemotherapy was underlined by the subjectively perceived impaired olfactory function during this time. In addition almost every fourth patient presented with a depressed mood at the beginning of chemotherapy. Patients should be informed about possible transient olfactory impairment during/immediately after chemotherapy.
睾丸癌是15至35岁年轻男性中最常见的恶性疾病。铂类化疗方案是晚期疾病的首选治疗方法。这种治疗也会因细胞毒性活性物质产生不良反应，如嗅觉功能障碍。因此，本研究的目的是监测睾丸癌患者化疗期间及化疗后6个月的嗅觉功能。共有17例接受化疗（平均2.47个周期±0.5）的患者（平均年龄31.06±10.26岁）纳入本研究。在化疗完成前以及化疗完成后的第42天、90天和180天，通过“嗅棒”评估气味阈值、辨别力和识别力。此外，还评估了患者对嗅觉功能和抑郁症状的评分。与基线（10.4±2.20）相比，第90天的阈值评分显著降低（8.0±2.51）（p=0.014），并在第180天几乎完全恢复（9.65±3.26）。在治疗期间，气味辨别和识别能力未显示出显著变化。化疗期间/化疗后立即出现的嗅觉功能下降，在这段时间内患者主观感觉到的嗅觉功能受损得到了证实。此外，几乎每四名患者在化疗开始时都表现出情绪低落。应告知患者化疗期间/化疗后立即可能出现的短暂嗅觉损害。
