GRP78 蛋白在卵巢癌患者中的表达及药物靶向治疗的前景。
GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach.
机构信息
School of Pharmaceutical Sciences, University of Geneva/university of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.
出版信息
J Oncol. 2012;2012:468615. doi: 10.1155/2012/468615. Epub 2012 Mar 18.
Abstract
Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell.
摘要
葡萄糖调节蛋白 78kD（GRP78）是一种主要位于内质网（ER）中的伴侣蛋白。这种蛋白质在成年细胞中的含量通常较低，但在包括葡萄糖剥夺和缺氧在内的 ER 应激时，其表达会被触发。在肿瘤细胞中，GRP78 过表达，部分蛋白位于细胞表面。本文介绍了 GRP78 在卵巢癌中的生理学作用及其作为卵巢癌细胞靶向药物递送系统的潜在用途。
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