Stultiens Audrey, Ho T T Giang, Nusgens Betty V, Colige Alain C, Deroanne Christophe F
Laboratory of Connective Tissues Biology; GIGA-Cancer; University of Liège; Tour de Pathologie; Sart-Tilman, Belgium.
Commun Integr Biol. 2012 Jan 1;5(1):99-101. doi: 10.4161/cib.18553.
The small GTPases of the Rho family are key signaling molecules regulating a plethora of biological pathways. They can exert diverse, sometimes opposite, contributions to specific cellular processes explaining why their regulation and their crosstalk must be finely tuned. Several mechanisms driving crosstalk between Rho GTPases have been described in the literature. They implicate proteins regulating their activity or common downstream effectors. Among the proteins regulating Rho GTPases cycling, RhoGDIs were viewed until very recently as passive inhibitors. Here, we will focus on recent data supporting a role for RhoGDIalpha in the crosstalk between RhoGTPases and present our results suggesting that "preferential" RhoGDIalpha-mediated crosstalk takes place between closely related Rho GTPases.
Rho家族的小GTP酶是调节众多生物学途径的关键信号分子。它们可对特定细胞过程产生多样的、有时甚至相反的作用，这解释了为何必须对其调节及相互作用进行精细调控。文献中已描述了几种驱动Rho GTP酶之间相互作用的机制。这些机制涉及调节其活性的蛋白质或共同的下游效应器。在调节Rho GTP酶循环的蛋白质中，直到最近Rho鸟苷酸解离抑制剂（RhoGDIs）还被视为被动抑制剂。在此，我们将聚焦于支持RhoGDIα在Rho GTP酶相互作用中发挥作用的最新数据，并展示我们的结果，表明“优先的”RhoGDIα介导的相互作用发生在密切相关的Rho GTP酶之间。
