Blum Arnon, Zarqh Oleg, Peleg Aviva, Sirchan Rizak, Blum Nava, Salameh Yosef, Ganaem Maged
Department of Medicine, Baruch Padeh Poria Hospital, Lower Galilee, Israel.
Am J Orthop (Belle Mead NJ). 2012 Feb;41(2):87-91.
Angiogenesis is an important step in bone fracture healing. In this article, we report on the healing of long bone fractures, and the involvement of the vascular and the inflammatory systems in the process. We conducted a prospective study of 20 healthy adults with traumatic long bone fracture. One week after fracture, and then 1 month later, we evaluated markers of inflammation: vascular responsiveness (brachial endothelial function and ankle brachial index) and inflammatory and cytokine levels osteopontin [OPN], E-selectin, and vascular endothelial growth factor [VEGF]). Long bone fractures caused intense vascular and inflammatory responses, represented by high levels of OPN, Eselectin, and VEGF. In vivo measurements demonstrated severe endothelial dysfunction, which could support the idea that the vascular system is recruited to build new blood vessels that support bone regeneration.
血管生成是骨折愈合过程中的重要一步。在本文中，我们报告了长骨骨折的愈合情况，以及血管系统和炎症系统在这一过程中的参与情况。我们对20名患有创伤性长骨骨折的健康成年人进行了一项前瞻性研究。骨折后1周，然后在1个月后，我们评估了炎症标志物：血管反应性（肱动脉内皮功能和踝臂指数）以及炎症和细胞因子水平（骨桥蛋白[OPN]、E-选择素和血管内皮生长因子[VEGF]）。长骨骨折引发了强烈的血管和炎症反应，表现为OPN、E-选择素和VEGF水平升高。体内测量显示存在严重的内皮功能障碍，这可能支持以下观点：血管系统被募集来构建支持骨再生的新血管。
