通过硫醇-马来酰亚胺点击化学合成轮烷和生物功能化伪轮烷。
Rotaxanes and biofunctionalized pseudorotaxanes via thiol-maleimide click chemistry.
机构信息
Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459, USA.
出版信息
Org Lett. 2012 Apr 20;14(8):2082-5. doi: 10.1021/ol300614z. Epub 2012 Apr 6.
PMID:22482430
Abstract
Base-catalyzed thiol-maleimide click chemistry has been applied to the synthesis of neutral donor-acceptor [2]rotaxanes in good yield. This method is extended further to the synthesis of a glutathione-functionalized [2]pseudorotaxane, a precursor to integrated conjugates of interlocked molecules with proteins and enzymes.
摘要
碱基催化的巯基-马来酰亚胺点击化学已被应用于中性给体-受体[2]轮烷的合成，产率良好。该方法进一步扩展到谷胱甘肽功能化[2]假轮烷的合成，这是具有蛋白质和酶的分子内化合物的整合缀合物的前体。
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