靶向 CML 中的β-连环蛋白：白血病干细胞要小心！
Targeting β-catenin in CML: leukemia stem cells beware!
机构信息
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Cell Stem Cell. 2012 Apr 6;10(4):351-3. doi: 10.1016/j.stem.2012.03.006.
PMID:22482499
Abstract
In this issue of Cell Stem Cell, Heidel et al. (2012) use genetic and pharmacological approaches to reveal that Wnt/β-catenin signaling is required for leukemic stem cell (LSC) maintenance in chronic myeloid leukemia. They demonstrate that β-catenin inactivation targets imanitib-resistant LSCs in vivo.
摘要
在本期《细胞干细胞》中，Heidel 等人（2012）利用遗传和药理学方法揭示了 Wnt/β-catenin 信号通路对于慢性髓性白血病中白血病干细胞（LSC）的维持是必需的。他们证明了β-catenin 的失活可以靶向伊马替尼耐药的 LSCs 并在体内发挥作用。
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