Abouali Omid, Modareszadeh Amirreza, Ghaffarieh Alireza, Tu Jiyuan
School of Mechanical Engineering, Shiraz University, 71348-51154, Shiraz, Iran.
J Biomech Eng. 2012 Feb;134(2):021002. doi: 10.1115/1.4005762.
The aqueous humor (AH) flow in the anterior chamber (AC) due to saccadic movements is investigated in this research. The continuity, Navier-Stokes and energy equations in 3D and unsteady forms are solved numerically and the saccadic motion was modeled by the dynamic mesh technique. Firstly, the numerical model was validated for the saccadic movement of a spherical cavity with analytic solutions and experimental data where excellent agreement was observed. Then, two types of periodic and realistic saccadic motions of the AC are simulated, whereby the flow field is computed for various saccade amplitudes and the results are reported for different times. The results show that the acting shear stress on the corneal endothelial cells from AH due to saccadic movements is much higher than that due to normal AH flow by buoyancy induced due to temperature gradient. This shear stress is higher on the central region of the cornea. The results also depict that eye saccade imposes a 3D complicated flow field in the AC consist of various vortex structures. Finally, the enchantment of heat transfer in the AC by AH mixing as a result of saccadic motion is investigated.
本研究对由于眼球快速运动导致的前房内房水流动进行了研究。采用数值方法求解了三维非定常形式的连续性方程、纳维-斯托克斯方程和能量方程，并通过动态网格技术对眼球快速运动进行了建模。首先，利用解析解和实验数据对球形腔的眼球快速运动数值模型进行了验证，结果显示二者吻合良好。然后，模拟了前房两种周期性且符合实际的眼球快速运动，计算了不同扫视幅度下的流场，并给出了不同时刻的结果。结果表明，眼球快速运动引起的房水作用于角膜内皮细胞的剪切应力远高于由温度梯度引起的浮力导致的正常房水流动所产生的剪切应力。角膜中央区域的这种剪切应力更高。结果还表明，眼球扫视在前房内形成了一个包含各种涡旋结构的三维复杂流场。最后，研究了眼球快速运动导致的房水混合对前房内传热的增强作用。
