Ooi Ean-Hin, Ng Eddie Yin-Kwee
School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Comput Biol Med. 2008 Feb;38(2):252-62. doi: 10.1016/j.compbiomed.2007.10.007. Epub 2007 Nov 19.
The need to develop accurate representation of the human eye for the purpose of physiological studies is important to ensure that the predicted results are reliable. The presence of natural circulation of aqueous humor (AH) is evident from clinical, experimental and simulated observations. Most of the thermal models of the human eye that are found in the literature, however, had assumed a stagnant AH inside the anterior chamber. In this paper, a two-dimensional model of the human eye is developed where the circulation of AH inside the anterior chamber is included. The effects of the AH flow on the temperature distribution inside the eye are investigated. The natural circulation of AH is found to increase the temperature and distorts the temperature profile in the cornea and anterior chamber. Further investigations, where an artificial heat source is introduced inside the human eye suggest that AH flow plays a role in the heat transfer at the anterior region of the eye although this has yet to be quantified experimentally.
为了进行生理学研究而开发准确的人眼模型对于确保预测结果的可靠性非常重要。从临床、实验和模拟观察中可以明显看出房水（AH）存在自然循环。然而，文献中发现的大多数人眼热模型都假设前房内的房水是静止的。在本文中，开发了一个人眼二维模型，其中包括前房内房水的循环。研究了房水流动对眼内温度分布的影响。发现房水的自然循环会增加温度并扭曲角膜和前房内的温度分布。进一步的研究表明，虽然尚未通过实验进行量化，但当在人眼内部引入人工热源时，房水流动在眼前部区域的热传递中起作用。
