Department of Obstetrics and Gynecology, College of Medicine, University of Kwandong, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea.
Taiwan J Obstet Gynecol. 2012 Mar;51(1):60-5. doi: 10.1016/j.tjog.2012.01.012.
To investigate the risks of increasing maternal age on the perinatal and obstetric outcomes.
Information about 29,760 singleton pregnancies delivered between 2005 and 2008 was extracted from our database. Patients were categorized into four groups according to age: 20-29 years, 30-34 years, 35-39 years, and ≥40 years. Multivariable logistic regression analysis was used to evaluate the adjusted odd ratios (AORs) of adverse pregnancy outcomes according to maternal age after adjusting for parity, body mass index, medical history and use of in vitro fertilization.
The majority of adverse perinatal outcomes were associated with a maternal age ≥35 years as follows: low birth weight (AOR 1.2 and 1.6 for women aged 35-39 years and ≥40 years, respectively); Apgar score < 7 at 1 minute (AOR: 1.7 and 1.8); and chromosomal anomaly (AOR: 2.7 and 12.3). However, women aged ≥30 years also had greater risks for adverse maternal outcomes such as: gestational diabetes (AOR: 2.0, 3.6 and 5.1 for women aged 30-34 years, 35-39 years and ≥40 years, respectively); placenta previa (AOR: 1.6, 2.1 and 3.6); and cesarean delivery (AOR: 1.5, 2.3, and 4.1), as well as adverse fetal outcomes such as: preterm delivery (AOR: 1.2, 1.4 and 1.8) and neonatal intensive care unit transfer (AOR: 1.1, 1.2, and 1.6).
Increasing maternal age is an independent and substantial risk factor for adverse perinatal and obstetric outcomes. These adverse outcomes become more common as increasing maternal age without a clear cutoff age.
探讨产妇年龄增加对围产儿和产科结局的风险。
从我们的数据库中提取了 2005 年至 2008 年间 29760 例单胎妊娠的信息。根据年龄将患者分为四组：20-29 岁、30-34 岁、35-39 岁和≥40 岁。采用多变量逻辑回归分析，在调整了产次、体重指数、既往病史和体外受精使用情况后，根据产妇年龄评估不良妊娠结局的调整比值比（AOR）。
大多数不良围产儿结局与产妇年龄≥35 岁有关，包括低出生体重（35-39 岁和≥40 岁的女性分别为 AOR1.2 和 1.6）；1 分钟时 Apgar 评分<7（AOR：1.7 和 1.8）；和染色体异常（AOR：2.7 和 12.3）。然而，年龄≥30 岁的女性也有更高的不良母体结局风险，如：妊娠期糖尿病（AOR：2.0、3.6 和 5.1，年龄 30-34 岁、35-39 岁和≥40 岁的女性）；前置胎盘（AOR：1.6、2.1 和 3.6）；剖宫产（AOR：1.5、2.3 和 4.1），以及不良胎儿结局，如：早产（AOR：1.2、1.4 和 1.8）和新生儿重症监护病房转移（AOR：1.1、1.2 和 1.6）。
产妇年龄增加是不良围产儿和产科结局的独立且重要的危险因素。随着产妇年龄的增加而没有明确的年龄界限，这些不良结局变得更加常见。
