Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
Org Lett. 2012 Apr 20;14(8):2164-7. doi: 10.1021/ol3006997. Epub 2012 Apr 6.
Thioethers have been proven to be reliable directing groups for palladium catalyzed alkenylation of arenes via C-H activation. Mechanistic investigation reveals that the C-H cleavage of arenes is the turnover-limiting step, and an acetate-bridged dinuclear cyclopalladation intermediate is involved. The alkenylated thioethers can be easily removed and transformed into a variety of useful groups.
硫醚已被证明是通过 C-H 活化钯催化芳基烯基化反应的可靠导向基团。机理研究表明，芳基的 C-H 断裂是决速步骤，涉及到一个醋酸桥联双核环钯化中间体。烯基化的硫醚可以很容易地被去除，并转化为各种有用的基团。
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