Gorecka M
Arch Immunol Ther Exp (Warsz). 1979;27(3):365-71.
An attempt was made to develop as in vitro model of inflammation which would allow the study of the inflammatory process on the subcellular level and on the influence of PGE1 and db-cAMP on permeability of lysosomal membranes of liver lymphocytes. The results showed that the in vitro histamine test permits evaluation of early changes in the lysosomal membranes. Drugs such as acetylsalicylic acid, hydrocortisone, as well as PGE1 and db-cAMP exerted a stabilizing influence on the lysosomal membranes of rat lymphocytes.
我们尝试建立一种炎症的体外模型，以便在亚细胞水平研究炎症过程以及前列腺素E1（PGE1）和二丁酰环磷腺苷（db - cAMP）对肝淋巴细胞溶酶体膜通透性的影响。结果表明，体外组胺试验可评估溶酶体膜的早期变化。乙酰水杨酸、氢化可的松以及PGE1和db - cAMP等药物对大鼠淋巴细胞的溶酶体膜具有稳定作用。
