New South Wales Health Department, North Sydney 2060, Australia.
Chemosphere. 2012 Jul;88(3):316-22. doi: 10.1016/j.chemosphere.2012.03.003. Epub 2012 Apr 6.
A total of 265000 m(3) of dioxin contaminated soil and sediments from past industrial activity was treated on site in an urban setting in Sydney, Australia. To respond to local community concerns about potential dioxin exposure from fugitive emissions a human biomonitoring study was undertaken.
To determine whether local residents were exposed to significant amounts of dioxin from the remediation process.
Blood samples were collected from local residents around the site and a representative metropolitan control group. They were pooled within age and sex strata and the change in dioxin concentrations over the remediation period and a summary of the mid point and post remediation dioxin concentrations were compared between groups. Information on dietary intake was collected to look for possible confounding.
The mean dioxin Toxic Equivalent concentrations (TeQ) decreased among both the local resident and control groups over the remediation period by 1.9 and 2.1 pg gm(-1) lipid respectively. Modelled blood concentrations adjusting for age and sex did not detect a significant difference between groups for changes in either TeQ or 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8 TCDD). The summary measure approach did however demonstrate that the 2,3,7,8 TCDD concentrations among the local resident group was approximately 0.7 pg g(-1) lipid higher compared to the control group post remediation. There were no significant changes in dietary intake sources of dioxin.
Biomonitoring demonstrated that local residents were not exposed to significant quantities of dioxin. Large scale remediation of dioxin contaminated land can be safely undertaken in an urban setting.
在澳大利亚悉尼的一个城市环境中，现场处理了总计 265000 立方米来自过去工业活动的二恶英污染土壤和沉积物。为回应当地社区对修复过程中可能的二恶英暴露的担忧，进行了一项人体生物监测研究。
确定当地居民是否因修复过程而接触到大量二恶英。
在该地点周围和代表性的大都市对照组中收集当地居民的血液样本。根据年龄和性别分层将其汇集，并比较修复期间二恶英浓度的变化，以及两组之间修复中和修复后的二恶英浓度的中位数。收集有关饮食摄入的信息以寻找可能的混杂因素。
在修复期间，当地居民和对照组的二恶英毒性当量浓度（TeQ）平均值分别降低了 1.9 和 2.1 pg gm(-1) 脂质。调整年龄和性别后，模型化的血液浓度未检测到两组之间 TeQ 或 2,3,7,8-四氯二苯并对二恶英（2,3,7,8-TCDD）的变化有显著差异。然而，综合测量方法确实表明，与对照组相比，修复后当地居民组的 2,3,7,8-TCDD 浓度高约 0.7 pg g(-1) 脂质。二恶英饮食摄入源没有发生显著变化。
生物监测表明，当地居民没有接触到大量的二恶英。在城市环境中可以安全地进行大规模的二恶英污染土地修复。
