Research Department of Chemistry, VHNSN College, Virudhunagar-626 001, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:250-9. doi: 10.1016/j.saa.2012.03.024. Epub 2012 Mar 18.
A new series of novel o-acetoacetotoluidide derived Schiff base and its metal complexes have been synthesized and structurally characterized. Elemental analysis, magnetic and spectroscopic data suggest that the complexes have octahedral geometry. Binding of these complexes with CT-DNA has been analyzed by absorption spectra, viscosity, cyclicvoltammetry and molecular docking analysis. Detailed analysis reveals that the metal complexes intercalate into the DNA base stack as intercalators. All the metal complexes cleave the pBR322 DNA upon irradiation. Antibacterial and antifungal activities of the ligand and its metal complexes are also explored and it has been observed that the complexes exhibit excellent activity against all types of bacteria and fungi than the ligand.
已经合成了一系列新型的 o-乙酰乙酰替丁基席夫碱及其金属配合物，并对其结构进行了表征。元素分析、磁性和光谱数据表明，这些配合物具有八面体几何构型。通过吸收光谱、粘度、循环伏安法和分子对接分析研究了这些配合物与 CT-DNA 的结合。详细分析表明，金属配合物作为嵌入剂嵌入到 DNA 碱基对中。所有金属配合物在光照下都能切割 pBR322 DNA。还研究了配体及其金属配合物的抗菌和抗真菌活性，观察到配合物对所有类型的细菌和真菌的活性都优于配体。
