Institute of Neuroscience and Physiology, Gillberg Neuropsychiatry Centre, University of Gothenburg, Göteborg, Sweden.
Eur Child Adolesc Psychiatry. 2012 Aug;21(8):421-32. doi: 10.1007/s00787-012-0274-9. Epub 2012 Apr 7.
The aim of this study was to study long-term outcome of physical health and self-injurious behaviour (SIB) in anorexia nervosa (AN). Fifty-one adolescent-onset AN cases, originally recruited after community screening, and 51 matched controls (COMP) were interviewed regarding somatic problems and SIB and physically examined 18 years after AN onset, at mean age 32 years. Six individuals had an eating disorder (ED). No one had died. The AN group weighed less than the COMP group. The frequency of somatic problems did not differ between groups. Dental enamel lesions and shorter than expected stature occurred only in the AN group. Dysdiadochokinesis was overrepresented in the AN group and age of AN onset was lower among those with the neurological deficit. Severe SIB occurred only in the AN group, predominantly during adolescence. To conclude, somatic problems were common in both groups. Most individuals in the AN group had recovered from their ED, but weight revealed a persistent restricted eating behaviour.
本研究旨在探讨青少年起病的神经性厌食症(AN)患者的身体健康和自伤行为(SIB)的长期预后。51 例 AN 患者为社区筛查后入选,51 例匹配的对照组(COMP),分别在 AN 发病 18 年后进行访谈,了解躯体问题和 SIB,并进行体格检查,平均年龄 32 岁。6 例为进食障碍(ED)。无人死亡。AN 组体重低于 COMP 组。两组躯体问题的频率无差异。仅在 AN 组中发现牙釉质损伤和预期身高不足。神经缺陷患者的运动不协调性更常见,AN 发病年龄更低。严重的 SIB 仅发生在 AN 组,主要发生在青少年期。总之,两组均有常见的躯体问题。大多数 AN 组患者已从 ED 中恢复,但体重仍显示持续的限制饮食行为。