Wentz Elisabet, Gillberg I Carina, Anckarsäter Henrik, Gillberg Christopher, Råstam Maria
Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, Göteborg University, Otterhällegatan 12 B, Göteborg SE-411 18, Sweden.
Int J Eat Disord. 2009 Sep;42(6):483-91. doi: 10.1002/eat.20664.
To study reproduction in a representative group of anorexia nervosa (AN) cases.
Fifty-one adolescent-onset AN cases (48 women; three men), originally recruited after community screening, and 51 matched comparison cases (COMP) were interviewed 18 years after AN onset at a mean age of 32 years, regarding pregnancies and early development of the children.
The results of the 48 AN and 48 COMP group women are reported in the present study. Six women still had an eating disorder (ED), none of whom had become a mother. Twenty-seven women in the AN group and 31 women in the COMP group had children. Three women had an ED during pregnancy. Mean age at birth of the first child was lower in the AN group. Five AN women reported postpartum depression. Children in the AN group had significantly lower birth weight than the children in the COMP group. No other complications during pregnancy and the neonatal period differed across groups. Feeding difficulties were not overrepresented among the children of the AN group.
Adults who had recovered from teenage-onset AN did not differ in most aspects from matched controls with respect to pregnancies and development of their offspring.
研究一组具有代表性的神经性厌食症（AN）病例的生育情况。
51例青少年起病的AN病例（48名女性；3名男性），最初是在社区筛查后招募的，以及51例匹配的对照病例（COMP），在AN发病18年后、平均年龄32岁时接受访谈，内容涉及妊娠情况及子女的早期发育。
本研究报告了48例AN组女性和48例COMP组女性的结果。6名女性仍患有饮食失调症（ED），她们均未生育。AN组有27名女性和COMP组有31名女性育有子女。3名女性在孕期患有ED。AN组第一个孩子的平均出生年龄较低。5名AN组女性报告有产后抑郁症。AN组孩子的出生体重显著低于COMP组孩子。妊娠和新生儿期的其他并发症在两组间无差异。喂养困难在AN组孩子中并无过多表现。
青少年起病的AN康复后的成年人在妊娠及后代发育的大多数方面与匹配的对照组并无差异。
