Department of Pathology, Faculty of Medicine, UAE University, P.O. Box 17666, Al Ain, United Arab Emirates.
Arch Gynecol Obstet. 2012 Aug;286(2):373-8. doi: 10.1007/s00404-012-2324-4. Epub 2012 Apr 7.
The American Diabetes Association has endorsed the International Association of Diabetes and Pregnancy Groups (IADPSG) recommendation that every pregnant woman should undergo the 75 g oral glucose tolerance test (OGTT) to screen for gestational diabetes mellitus (GDM).
To find the cost and workload implications of switching from the current two-step screening of GDM to the one-step IADPSG approach.
The cost (US $) and laboratory workload units (WLU) were calculated for three possible strategies: (1) 50 g glucose screen, if positive, followed by the 100 g OGTT; (2) universal 75 g OGTT; and (3) screening with the initial fasting plasma glucose of the OGTT.
For the 1,101 pregnant women screened in 1 year, the cost of the three strategies was $ 31,985, $ 55,250 and $ 35,875, respectively; the laboratory burden was 28,975 WLU, 18,662 WLU and 12,215 WLU, respectively.
Switching to the one-step, strategy 2 (IADPSG) would increase the cost by 42 % but decrease the laboratory workload by 36 % compared to the two-step, strategy 1. However, an initial screen by the fasting plasma glucose of the OGTT is the ideal strategy, both in terms of cost and laboratory workload.
美国糖尿病协会已经认可了国际妊娠糖尿病协会(IADPSG)的建议,即每个孕妇都应进行 75g 口服葡萄糖耐量试验(OGTT)筛查妊娠期糖尿病(GDM)。
确定从当前两步筛查 GDM 切换到一步 IADPSG 方法的成本和工作量影响。
计算了三种可能策略的成本(美元)和实验室工作量单位(WLU):(1)50g 葡萄糖筛查,如果阳性,则进行 100g OGTT;(2)通用 75g OGTT;(3)初始 OGTT 空腹血浆葡萄糖筛查。
在 1 年内对 1101 名孕妇进行筛查,三种策略的成本分别为 31985 美元、55250 美元和 35875 美元;实验室负担分别为 28975 WLU、18662 WLU 和 12215 WLU。
与两步筛查策略 1 相比,转换为一步筛查策略 2(IADPSG)将使成本增加 42%,但实验室工作量减少 36%。然而,初始 OGTT 空腹血浆葡萄糖筛查是最理想的策略,无论是在成本还是实验室工作量方面。