Sakaguchi Hirokazu, Kamei Motohiro, Nishida Kentaro, Terasawa Yasuo, Fujikado Takashi, Ozawa Motoki, Nishida Kohji
Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, E-7, Suita, Osaka 565-0871, Japan.
J Artif Organs. 2012 Sep;15(3):295-300. doi: 10.1007/s10047-012-0642-8. Epub 2012 Apr 7.
The purpose of this study was to investigate the surgical procedures involved in the implantation of a newly developed direct optic nerve electrode device for inducing artificial vision. The electrode device comprised seven wire stimulation electrodes and a return electrode (diameter 50 μm), one manipulation rod (diameter 100 μm), and a cylindrical silicone board (diameter 2.0 mm). The stimulation electrodes and the manipulation rod protruded through the board to allow implantation of the electrode tips into the optic disc of the rabbit eye. The surgical procedures required to insert the device into the vitreous cavity and implant the device into the optic disc were evaluated. When the electrodes were stimulated, electrically evoked potentials (EEPs) were recorded at the visual cortex. The electrode device was inserted into the vitreous cavity with no damage using a trocar through a scleral incision. The device was easily manipulated using vitreoretinal forceps in the vitreous cavity, and the electrode tips were implanted into the optic disc in a single insertion after vitrectomy. When electrical stimulation was applied, EEPs were recorded from all electrode pairs. The newly developed electrode device was inserted into the eye and implanted into the optic nerve disc smoothly and safely, suggesting that these surgical procedures are useful for our artificial vision system.
本研究的目的是调查植入一种新开发的用于诱导人工视觉的直接视神经电极装置所涉及的外科手术过程。该电极装置包括七个线状刺激电极和一个返回电极（直径50μm）、一根操纵杆（直径100μm）以及一个圆柱形硅胶板（直径2.0mm）。刺激电极和操纵杆穿过该板伸出，以便将电极尖端植入兔眼的视盘。评估了将该装置插入玻璃体腔并将其植入视盘所需的外科手术过程。当刺激电极时，在视觉皮层记录到电诱发电位（EEPs）。使用套管针通过巩膜切口将电极装置无损地插入玻璃体腔。在玻璃体腔内使用玻璃体视网膜镊可轻松操纵该装置，并且在玻璃体切除术后单次插入即可将电极尖端植入视盘。当施加电刺激时，从所有电极对均记录到了EEPs。新开发的电极装置顺利且安全地插入眼内并植入视神经盘，表明这些外科手术过程对我们的人工视觉系统有用。
