钌-吡唑配合物的合成、表征及抗癌活性。
Synthesis, characterization, and anticancer activity of ruthenium-pyrazole complexes.
机构信息
Department of Chemistry, University of Louisiana at Lafayette, LA 70504, USA. .
出版信息
J Inorg Biochem. 2012 Jun;111:33-9. doi: 10.1016/j.jinorgbio.2012.02.022. Epub 2012 Mar 4.
A series of new water soluble Ru(III) pyrazole complexes mer-[RuCl(3)(DMSO-S)(pyz)(2)] 1, mer-[RuCl(3)(DMSO-S)(DMSO-O)(pyz)] 2, mer-[RuCl(3)(bpy)(dmpyz)] 3, and mer-[RuCl(3)(DMSO-S)(dmpyz)(2)] 4 (pyz=pyrazole; dmpyz=3,5-dimethylpyrazole, bpy=2,2'-bipyridine) have been synthesized and characterized by use of a combination of spectroscopy (IR and UV-visible), X-ray diffraction, and cyclic voltammetry. The molecular X-ray structure of all reported compounds (1-4) revealed distorted octahedral coordination around ruthenium. The cytotoxicity assay on human breast cancer cells (MCF7) demonstrated that compounds 1 and 4 affect cell viability, whereas compounds 2 and 3 do not show appreciable activity. The IC(50) values for 1 and 4 lie within the range of 71-32μM in MCF7 cells.
一系列新的水溶性 Ru(III)吡唑配合物 mer-[RuCl(3)(DMSO-S)(pyz)(2)] 1、mer-[RuCl(3)(DMSO-S)(DMSO-O)(pyz)] 2、mer-[RuCl(3)(bpy)(dmpyz)] 3 和 mer-[RuCl(3)(DMSO-S)(dmpyz)(2)] 4（pyz=吡唑；dmpyz=3,5-二甲基吡唑，bpy=2,2'-联吡啶）已通过光谱（IR 和 UV-可见）、X 射线衍射和循环伏安法的组合进行了合成和表征。所有报道的化合物（1-4）的分子 X 射线结构显示钌周围的扭曲八面体配位。对人乳腺癌细胞（MCF7）的细胞毒性测定表明，化合物 1 和 4 影响细胞活力，而化合物 2 和 3 没有表现出明显的活性。化合物 1 和 4 在 MCF7 细胞中的 IC(50)值在 71-32μM 范围内。
Zotero 插件