DXA Unit, St. Vincent's University Hospital, Dublin, 4, Ireland.
Ir J Med Sci. 2013 Mar;182(1):29-32. doi: 10.1007/s11845-012-0818-5. Epub 2012 Apr 7.
The effect of immunomodulator therapy (IMT) for multiple sclerosis (MS) on bone turnover is unknown.
The aim of this study was to assess bone turnover in MS patients on IMT.
MS patients (n = 29) on maintenance IMT had repeat measurement of bone mineral density (BMD) after a 4.0 ± 0.4 years; bone turnover markers (BTM) were measured at the time of repeat BMD.
BMD was unchanged at the spine but declined at the hip. BTMs, both resorption and formation, were reduced compared to normative range that may indicate an anti-resorptive action of IMT. Significant negative correlations were noted between BTMs and changes in BMD at spine but not hip.
These observations suggest that IMT may have a beneficial effect on spinal bone by an antiresorptive action. A prospective study of the effect of IMT on BMD and bone turnover is warranted.
免疫调节剂治疗（IMT）对多发性硬化症（MS）的骨转换的影响尚不清楚。
本研究旨在评估接受 IMT 的 MS 患者的骨转换情况。
29 例接受维持性 IMT 的 MS 患者在 4.0±0.4 年后重复测量骨密度（BMD）；在重复 BMD 时测量骨转换标志物（BTM）。
BMD 在脊柱处无变化，但在髋部下降。BTM（吸收和形成）均低于正常值，这可能表明 IMT 具有抗吸收作用。BTM 与脊柱 BMD 的变化之间存在显著的负相关，但与髋部 BMD 的变化无关。
这些观察结果表明，IMT 可能通过抗吸收作用对脊柱骨产生有益影响。有必要进行一项关于 IMT 对 BMD 和骨转换影响的前瞻性研究。
