橙皮素通过调节IκB-α的蛋白水平减轻脂多糖诱导的炎症。
Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α.
作者信息
Shin Hye-Sun, Kang Seong-Il, Yoon Seon-A, Ko Hee-Chul, Kim Se-Jae
机构信息
Department of Biology, Jeju National University, Jejusi, Jeju, Republic of Korea.
出版信息
Biosci Biotechnol Biochem. 2012;76(4):847-9. doi: 10.1271/bbb.110908. Epub 2012 Apr 7.
Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).
橙皮素是一种多甲氧基黄酮（PMF），在基本的苯并-γ-吡喃酮骨架上有五个甲氧基，在C(4)位置有一个羰基。在本研究中，我们研究了橙皮素在脂多糖（LPS）刺激的RAW 264.7细胞中的抗炎活性。橙皮素通过调节抑制蛋白κB-α（IκB-α）的蛋白质水平表现出抗炎活性。
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