Patel Kanika, Patel Dinesh Kumar
Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.
Cardiovasc Hematol Disord Drug Targets. 2022;22(3):144-154. doi: 10.2174/1871529X23666221207121955.
Plant and their active phytoproducts have been used in modern medicine and playing an important role in the health sectors since a very early age. Human beings need a considerable amount of these plant-based phytochemicals for their health. The flavonoidal class phytochemical is an important class of natural products in modern healthcare because of their different pharmacological activities and health benefits. Flavonoidal class phytochemicals have been used to treat diabetes and related secondary complications in humans. Flavonoids have antiapoptotic, anti-hyperlipidemic, anti-inflammatory, and anti-oxidant potential in the health sectors. Sinensetin, also called 3',4',5,6,7-pentametoksiflavon is a colorless compound with a molecular weight 372.37g/mol and is found to be present in the Orthosiphon stamineus.
In the present investigation, we aim to collect scientific information on sinensetin and analyze it for its biological potential and therapeutic benefits against various types of disorders and complications. Medicinal importance and pharmacological activities data have been collected and analyzed in the present work for sinensetin through literature data analysis of different research works. Google Science Direct, PubMed, Scopus, and Google Scholar were mainly searched to collect the scientific information in the present work. The present work analyzed sinensetin biological potential, pharmacological activities, and analytical aspects.
Literature data analysis of different scientific research works revealed the biological potential of phytochemicals in medicine, including flavonoids. Sinensetin has anti-tumor, antiinflammatory, anti-oxidant, anti-diabetic, and antibacterial activities through their testing in different in vitro and in vivo models. Sinensetin has physiological functions, including anti-oxidant, antiinflammation, and anti-cancer potential in medicine. Scientific data analysis signified the biological importance of sinensetin against tumors, gastric cancer, colorectal cancer, breast cancer, diabetes, influenza H1N1 infection, obesity, inflammation, colitis, brain disorders, and microbial infections. Further biological potential of sinensetin on enzymes and angiogenesis has been analyzed in the present work. Sinensetin was isolated through different analytical and extraction techniques, including chromatographic techniques.
Literature data analysis signified sinensetin's biological potential and pharmacological activities in medicine.
植物及其活性植物产物自很早以前就已应用于现代医学，并在健康领域发挥着重要作用。人类健康需要大量这类基于植物的植物化学物质。黄酮类植物化学物质是现代医疗保健中一类重要的天然产物，因其具有不同的药理活性和健康益处。黄酮类植物化学物质已被用于治疗人类糖尿病及相关继发性并发症。黄酮类物质在健康领域具有抗凋亡、抗高血脂、抗炎和抗氧化潜力。橙皮素，也称为3',4',5,6,7-五甲氧基黄酮，是一种分子量为372.37g/mol的无色化合物，存在于猫须草中。
在本研究中，我们旨在收集有关橙皮素的科学信息，并分析其针对各类疾病和并发症的生物学潜力及治疗益处。通过对不同研究工作的文献数据分析，收集并分析了橙皮素的药用重要性和药理活性数据。本研究主要通过搜索谷歌学术搜索、PubMed、Scopus和谷歌学术来收集科学信息。本研究分析了橙皮素的生物学潜力、药理活性及分析方面。
对不同科研工作的文献数据分析揭示了植物化学物质（包括黄酮类）在医学中的生物学潜力。通过在不同体外和体内模型中的测试，橙皮素具有抗肿瘤、抗炎、抗氧化、抗糖尿病和抗菌活性。橙皮素具有生理功能，包括在医学中的抗氧化、抗炎和抗癌潜力。科学数据分析表明橙皮素对肿瘤、胃癌、结直肠癌、乳腺癌、糖尿病、甲型H1N1流感感染、肥胖症、炎症、结肠炎、脑部疾病和微生物感染具有生物学重要性。本研究进一步分析了橙皮素对酶和血管生成的生物学潜力。橙皮素通过不同的分析和提取技术（包括色谱技术）分离得到。
文献数据分析表明橙皮素在医学中的生物学潜力和药理活性。
