硫化氢在细胞凋亡调控中的作用。

Role of hydrogen sulfide in the regulation of cell apoptosis.

作者信息

Ryazantseva N V, Novitsky V V, Starikova E G, Kleptsova L A, Jakushina V D, Kaigorodova E V

机构信息

Siberian State Medical University, Russian Ministry of Health Care and Social Development, Tomsk, Russia.

出版信息

Bull Exp Biol Med. 2011 Oct;151(6):702-4. doi: 10.1007/s10517-011-1420-y.

DOI:10.1007/s10517-011-1420-y

PMID:22485212

Abstract

We studied the effect of a gas transmitter hydrogen sulfide (H(2)S) on the realization of apoptosis in Jurkat cells and mononuclear leukocytes from healthy donors. Treatment with H(2)S donor NaHS was accompanied by a dose-dependent intensification of cell death via apoptosis and necrosis. T-cell leukemia cells were more sensitive to H2S than mononuclear leukocytes from healthy donors. H(2)S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.

摘要

我们研究了气体递质硫化氢（H₂S）对健康供体Jurkat细胞和单核白细胞凋亡实现的影响。用H₂S供体硫氢化钠（NaHS）处理后，细胞通过凋亡和坏死导致的死亡呈剂量依赖性增强。T细胞白血病细胞比健康供体的单核白细胞对H₂S更敏感。H₂S诱导的细胞凋亡伴随着半胱天冬酶-3（caspase-3）和半胱天冬酶-9（caspase-9）的激活。